{"id":3032,"date":"2021-04-27T13:42:51","date_gmt":"2021-04-27T13:42:51","guid":{"rendered":"https:\/\/rehmantech.net\/demo\/bsscientifics\/?p=3032"},"modified":"2021-04-28T11:45:39","modified_gmt":"2021-04-28T11:45:39","slug":"saphyr-optical-genome-mapping-instrument","status":"publish","type":"post","link":"https:\/\/rehmantech.net\/demo\/bsscientifics\/research\/saphyr-optical-genome-mapping-instrument\/","title":{"rendered":"Saphyr Optical Genome Mapping Instrument"},"content":{"rendered":"

[vc_row css=”.vc_custom_1619606053693{margin-top: 450px !important;padding-bottom: 50px !important;background-color: #53565a !important;}”][vc_column][vc_single_image image=”3039″ img_size=”full” alignment=”center” css=”.vc_custom_1619606040659{margin-top: -400px !important;}”][vc_column_text]<\/p>\n

Saphyr Optical Genome Mapping Instrument<\/span><\/h2>\n
\n

Optical genome mapping using Saphyr\u00ae<\/sup>\u00a0reveals what\u2019s missing in your research. Rapidly\u00a0identify genome variation like never before with the high-throughput Saphyr system.<\/span><\/p>\n<\/div>\n

[\/vc_column_text][vc_btn title=”Download the Saphyr Brochure” style=”flat” shape=”rounded” color=”violet” size=”lg” align=”center” link=”url:https%3A%2F%2Fbionanogenomics.com%2Fwp-content%2Fuploads%2F2020%2F12%2FSaphyr-Brochure.pdf|title:Download%20the%20Saphyr%20Brochure|target:_blank|rel:nofollow” css=”.vc_custom_1619530705523{padding-top: 10px !important;padding-right: 15px !important;padding-bottom: 10px !important;padding-left: 15px !important;}”][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1619530948625{margin-top: 50px !important;margin-bottom: 50px !important;}” el_class=”arc_1″][vc_column width=”1\/6″][\/vc_column][vc_column width=”2\/3″][vc_column_text]<\/p>\n

STRUCTURAL VARIATION DISCOVERY PLATFORM<\/span><\/h2>\n
\n

Resolve large-scale structural variations missed by next-generation sequencing (NGS) systems<\/strong><\/p>\n

Large structural variations are responsible for many diseases and conditions, including cancers and developmental disorders. Optical genome mapping with Saphyr detects structural variations ranging from 500 bp to megabase pairs in length and offers assembly and discovery algorithms that far outperform sequencing-based technologies in sensitivity.<\/p>\n<\/div>\n

[\/vc_column_text][vc_single_image image=”3041″ img_size=”full” add_caption=”yes” alignment=”center” onclick=”link_image” lightbox=”yes” animation_type=”fadeInUp”][vc_column_text]For mosaic samples or heterogeneous cancer samples, Saphyr detects all types of structural variants down to 1% variant allele fraction. Saphyr provides this performance typically with a false positive rate of less than 2%. Saphyr also calls repeats and complex rearrangements.<\/p>\n

Detect large-scale structural variations for genetic disease, cancer, and cytogenomics.<\/strong><\/p>\n

[\/vc_column_text][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1618837660793{padding-top: 50px !important;padding-bottom: 50px !important;background-color: #fafafa !important;}” el_class=”arc_3″][vc_column width=”1\/6″][\/vc_column][vc_column width=”2\/3″][vc_row_inner][vc_column_inner width=”1\/2″][vc_single_image image=”3044″ img_size=”full” add_caption=”yes” alignment=”center” onclick=”link_image” lightbox=”yes” animation_type=”fadeInUp”][\/vc_column_inner][vc_column_inner width=”1\/2″]

OPTICAL GENOME MAPPING PROVIDES ENHANCED SPEED AND THROUGHPUT<\/h4><\/div>
<\/span><\/div><\/div>[vc_column_text]Rapid optical genome mapping using whole-genome imaging for human research applications<\/strong><\/p>\n

Saphyr features enhanced optics with adaptive loading of DNA utilizing machine learning. The Saphyr Instrument and high-capacity\u00a0Saphyr Chip\u00ae<\/sup>\u00a0combine to deliver genome maps at the speed and scale your research demands.<\/p>\n

    \n
  • Long molecules from 150,000 bp to multi-megabase pairs<\/li>\n
  • 15 Tbp output per Saphyr Chip for human samples for deep structural variant discovery (5 Tbp per flowcell of molecules larger than 150 kbp)<\/li>\n
  • Sample to structural variation call or genome scaffolding in as little as 4 days<\/li>\n<\/ul>\n

    [\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1618837619231{padding-top: 50px !important;}” el_class=”arc_5″][vc_column width=”1\/6″][\/vc_column][vc_column width=”2\/3″]

    SIMPLIFIED WORKFLOW<\/h2><\/div>
    <\/span><\/div><\/div>[vc_column_text]Optical genome mapping automation features and intelligent sample preparation simplify the process<\/strong><\/p>\n

    Saphyr optical genome mapping offers automated features that minimize hands-on time.<\/p>\n

      \n
    • Requires less than 3 minutes hands-on instrument time per chip<\/li>\n
    • Automatic optimization of run conditions based on sample characteristics maximizes throughput<\/li>\n
    • Saphyr Chip Clip protects sample integrity\u00a0and eliminates the need for instrument wash cycles between runs<\/li>\n<\/ul>\n

      [\/vc_column_text][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row wrap_container=”yes” no_padding=”yes” css=”.vc_custom_1619607006321{padding-top: 50px !important;padding-bottom: 50px !important;}”][vc_column][vc_row_inner css=”.vc_custom_1618676285170{margin-top: 50px !important;}”][vc_column_inner width=”1\/2″][vc_single_image image=”3047″ img_size=”full” add_caption=”yes” alignment=”center” onclick=”link_image” lightbox=”yes” animation_type=”fadeInUp”][\/vc_column_inner][vc_column_inner width=”1\/2″]

      HIGH SPEED DATA COLLECTION<\/h4><\/div>
      <\/span><\/div><\/div>[vc_column_text]Optical genome mapping automation features and intelligent sample preparation simplify the process<\/strong><\/p>\n

      Saphyr runs each genome in its own flow cell. Each Saphyr chip holds three flow cells, and 100x coverage of 3 human genomes is collected in less than 6 hours. That means 12 human samples at 100x coverage per day, or up to 96 per week.<\/p>\n

      For cases requiring higher coverage, like mosaic samples or heterogeneous tumors, the run can be extended up to 24 hours to collect as much as 400x coverage of a human genome for each of the three flowcells.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1618676109373{margin-top: 50px !important;margin-bottom: 50px !important;}”][vc_column width=”1\/6″][\/vc_column][vc_column width=”2\/3″][vc_row_inner css=”.vc_custom_1618676273602{margin-top: 50px !important;}”][vc_column_inner width=”1\/4″][vc_single_image image=”3048″ img_size=”medium” add_caption=”yes” alignment=”center” onclick=”link_image” lightbox=”yes” animation_type=”fadeInUp”][\/vc_column_inner][vc_column_inner width=”3\/4″]

      AUTOMATED SYSTEM HEALTH MONITORING<\/h2><\/div>
      <\/span><\/div><\/div>[vc_column_text]Remote quality control ensures maximum performance at all time<\/strong><\/p>\n

      The Saphyr Assure Service provides an optional (opt-in required) automated health monitoring feature that continuously inspects data quality and instrument performance. Performance issues are detected before data quality and performance are impacted allowing Bionano Support to proactively repair the system with minimal downtime.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1618837660793{padding-top: 50px !important;padding-bottom: 50px !important;background-color: #fafafa !important;}” el_class=”arc_3″][vc_column width=”1\/6″][\/vc_column][vc_column width=”2\/3″][vc_row_inner][vc_column_inner width=”1\/2″]

      INTELLIGENT DATA SOLUTIONS<\/h4><\/div>
      <\/span><\/div><\/div>[vc_column_text]Automate data analysis\u2014monitor and manage the Saphyr Instrument remotely<\/strong><\/p>\n

      The Bionano suite of hardware and software for Saphyr streamlines your workflow and reduces time to result.[\/vc_column_text]

      SAMPLE PREPARATION KITS<\/h4><\/div>
      <\/span><\/div><\/div>[vc_column_text]Extract high-molecular-weight DNA for human, plant and animal genome mapping<\/strong><\/p>\n

      The Bionano Prep DLS DNA labeling kit provides all the enzymes, dyes and buffers you need to label non-amplified DNA for Saphyr. Controls for validating the labeling biochemistry are also provided.[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″][vc_single_image image=”3051″ img_size=”full” add_caption=”yes” alignment=”center” onclick=”link_image” lightbox=”yes” animation_type=”fadeInUp”][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1619607612039{padding-top: 50px !important;padding-bottom: 50px !important;}” el_class=”arc_1″][vc_column width=”1\/4″][\/vc_column][vc_column width=”1\/2″]

      SAPHYR ORDERING INFORMATION AND BROCHURE<\/h2><\/div>
      <\/span><\/div><\/div>[vc_column_text]<\/p>\n
        \n
      • Saphyr System with Bionano Access Server: Catalog #90023<\/li>\n
      • Saphyr Compute Server: Catalog #80013<\/li>\n
      • Saphyr Chip G2.3* : Catalog #20366<\/li>\n
      • Saphyr Chip G2.2* : Catalog #20367<\/li>\n
      • Bionano Compute Server: Catalog #80014<\/li>\n<\/ul>\n

        *Compatible only with Saphyr System #90023 (Saphyr Instrument #60325)[\/vc_column_text][\/vc_column][vc_column width=”1\/4″][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"

        [vc_row css=”.vc_custom_1619606053693{margin-top: 450px !important;padding-bottom: 50px !important;background-color: #53565a !important;}”][vc_column][vc_single_image image=”3039″ img_size=”full” alignment=”center” css=”.vc_custom_1619606040659{margin-top: -400px !important;}”][vc_column_text] Saphyr Optical Genome Mapping Instrument Optical genome mapping using Saphyr\u00ae\u00a0reveals what\u2019s missing in your research. Rapidly\u00a0identify genome variation like never before with the high-throughput Saphyr system. [\/vc_column_text][vc_btn title=”Download the Saphyr Brochure” style=”flat” shape=”rounded” color=”violet” size=”lg” align=”center” link=”url:https%3A%2F%2Fbionanogenomics.com%2Fwp-content%2Fuploads%2F2020%2F12%2FSaphyr-Brochure.pdf|title:Download%20the%20Saphyr%20Brochure|target:_blank|rel:nofollow” css=”.vc_custom_1619530705523{padding-top: 10px !important;padding-right: 15px […]<\/p>\n","protected":false},"author":1,"featured_media":3039,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[48,4],"tags":[],"class_list":["post-3032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-microvicioner","category-research"],"featured_image_src":{"landsacpe":["https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-content\/uploads\/2021\/04\/Bionano-Saphyr-System_Chips_Circos-Plot-1140x445.png",1140,445,true],"list":["https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-content\/uploads\/2021\/04\/Bionano-Saphyr-System_Chips_Circos-Plot-463x348.png",463,348,true],"medium":["https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-content\/uploads\/2021\/04\/Bionano-Saphyr-System_Chips_Circos-Plot-300x154.png",300,154,true],"full":["https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-content\/uploads\/2021\/04\/Bionano-Saphyr-System_Chips_Circos-Plot.png",2315,1188,false]},"_links":{"self":[{"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/posts\/3032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/comments?post=3032"}],"version-history":[{"count":13,"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/posts\/3032\/revisions"}],"predecessor-version":[{"id":3053,"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/posts\/3032\/revisions\/3053"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/media\/3039"}],"wp:attachment":[{"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/media?parent=3032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/categories?post=3032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rehmantech.net\/demo\/bsscientifics\/wp-json\/wp\/v2\/tags?post=3032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}